Metabolic flexibility and insulin resistance
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چکیده
منابع مشابه
Metabolic flexibility and insulin resistance.
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of intramyocellular lipid and insulin resistance. The metabolic flexibility assessed by the ability to switch from fat to carbohydrate oxidation is usually impaired duri...
متن کاملMetabolic Flexibility and Insulin Resistance Short title: Metabolic flexibility and insulin resistance
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of intramyocellular lipid and insulin resistance. The metabolic flexibility assessed by the ability to switch from fat to carbohydrate oxidation is usually impaired duri...
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Combination of metabolic abnormalities in patients with high vascular risk is well known since long time. In his Banting lecture Reaven used the term Syndrome X for the description of the coexistence of these metabolic diseases. Other names as e.g. Deadly Quartet and insulin resistance syndrome emphasised the consequences and the possible cause of this syndrome. Most of the authors accept that ...
متن کاملEffects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance.
We hypothesized that acute lipid-induced insulin resistance would be attenuated in high-oxidative muscle of lean trained (LT) endurance athletes due to their enhanced metabolic flexibility and mitochondrial capacity. Lean sedentary (LS), obese sedentary (OS), and LT participants completed two hyperinsulinemic euglycemic clamp studies with and without (glycerol control) the coinfusion of Intrali...
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Atherosclerosis, a pathological process that underlies the development of cardiovascular disease, is the primary cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). T2DM is characterized by hyperglycemia and insulin resistance (IR), in which target tissues fail to respond to insulin. Systemic IR is associated with impaired insulin signaling in the metabolic tissue...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2008
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.90558.2008